chlorogenic acid mechanism of action

Cell studies indicated a neuroprotective effect against beta-amyloid proteins – the main cause of Alzheimer’s disease [50]. In the US, you may report side effects to the FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. Chlorogenic acid also has a mild psychostimulatory effect, about ⅓ of caffeine. In another trial on 30 people with prediabetes (impaired glucose tolerance), 400 mg, 3x/day oral chlorogenic acid reduced fasting blood sugar and insulin secretion, while improving insulin sensitivity [37]. The most abundant chlorogenic acids in green coffee beans are isomers of caffeoylquinic acids: 5-O-caffeoylquinic acid (5-CQA), 4-O-caffeoylquinic acid (4-CQA), and 3-O-caffeoylquinic acid (3-CQA) (Table 17.2). Elena Gagliardini, ... Norberto Perico, in Kidney Transplantation, Bioengineering and Regeneration, 2017, Chlorogenic acid (CA) is a phenolic compound widely found in fruits and vegetables (apples, pears, carrots, tomatoes, and sweet potatoes) and in coffee and tea.71 Recent evidence demonstrated the scavenging, antioxidant, and antiapoptotic activity of CA.72 In a murine model of cisplatin (CP)-induced AKI,72 the CA intraperitoneally injected 48 hours after the CP injection recovered renal function and reduced renal histologic abnormalities in terms of tubular necrosis, cast accumulation, and tubular dilatation. Selfhacked LLC does not provide medical advice, diagnosis, or treatment. Abstract: In this study, the antibacterial activity and mechanism of action of chlorogenic acid against bacteria were assessed. Research suggests it may also help lower blood sugar, improve mood, and help with infections. In mice and cultured brain cells, chlorogenic acid improved the survival of brain cells containing dopamine. Information is shared for educational purposes only. Call your doctor for medical advice about side effects. More clinical trials on larger populations are required to confirm these preliminary results. It is responsible for the astringent taste of coffee brews (Kreuml et al., 2013). Moreover, CA exhibited an inhibiting effect on apoptosis and autophagy, as suggested by the suppression of p53, caspase-3, cyclin D1, and microtubule-associated protein 1 light chain 3 isoform B (LC3B) expression. Remember to carefully follow your doctor’s recommendations when it comes to weight loss. Many of the users were satisfied with the results obtained. People respond differently to diets and supplements because everyone has unique DNA. In mice fed high doses of bile acids, supplementing their diet with chlorogenic acid prevented the development of colon cancer [63]. Animal studies suggest that CHAs are metabolized heavily by gut microbes, and their metabolites are detected mainly in plasma. [22][unreliable source? Ever try supplements that don’t seem to work? Contact your doctor or pharmacist if you notice any other side effects. Although a bit limited, the existing evidence suggests that chlorogenic acid may help improve blood sugar control and insulin sensitivity in both healthy and obese people. SelfHacked does not endorse any specific product, service, or treatment. Find out exactly which supplements he takes and what lifestyle changes Joe has made to maintain optimal health and prepare his body to fight off infections. Chlorogenic acid (CGA) (Fig. Moreover, chlorogenic acid also shows inhibitory activity against hepatitis B virus (HBV) in vivo and in vitro. Isolated chlorogenic acid also reduced blood pressure in another trial on 28 hypertensive people [24, 25, 26, 27, 28]. Join SelfHacked today and start the journey of improving your life, Get the Regimen of A Top Biohacker Preparing His Body to Fight Coronavirus, Avoid Coronavirus By Using the Best Supplements For Your Body. Multiple studies show that chlorogenic acid may reduce fasting blood sugar levels and insulin and glucose spikes following a meal. It is a polyphenolic compound abundant in many plants (Upadhyay and Rao, 2013), including tobacco leaves (Górnas et al., 2009), mulberry tree (Upadhyay and Rao, 2013), and coffee beans (Memon et al., 2010). CGA compounds and trans-hydroxycinnamic acids have been identified in freshly secreted human digestive fluid of 87 subjects, in free and conjugated forms, after 12-h fasting.21,29 Concentrations were in the order of magnitude of those observed in plasma after coffee consumption, with higher concentrations in conjugated forms.21,29 This finding indicates that digestive fluids are an excretion route for CGA and suggests the occurrence of CGA recycling in the human body by enterohepatic recirculation, since it is known that intestinal bacteria are able to hydrolyze sulfated and glucuronated phenolic compounds in the gastrointestinal tract, allowing for reabsorption.37,46 This is probably one of the reasons why in a few studies CGA and metabolites have been observed in baseline urine after 2-day low-phenolic diet followed by 24 h water and electrolytes intake only44 (unpublished data). Green coffee bean extract is the primary natural source of chlorogenic acid and is taken in a supplemental form [7]. Both green coffee extract and a natural supplement with chlorogenic acid and several plant extracts reduced body weight and blood fat levels in 2 clinical trials on 121 people with metabolic syndrome [38, 39]. Carlos is passionate about learning the mechanisms behind biological processes and communicating science to both academic and non-academic audiences. This suggests a potential benefit for people with neurodegenerative conditions such as Parkinson’s disease. Hsiu-Mei Chiang, ... Kuo-Ching Wen, in Coffee in Health and Disease Prevention, 2015, Chlorogenic acid inhibits MMP-3 expression, but not expression of MMP-1 and MMP-9, and does not restore UVB-irradiation-induced type I procollagen damage.9 However, chlorogenic acid has been reported to inhibit the MMP-9 activity of the hepatocellular carcinoma cell line (Hep3B). However, the studies should not be interpreted as supportive of any health benefit. Do not under any circumstances attempt to replace conventional cancer therapies with chlorogenic acid or any other supplements. In another trial on 9 healthy volunteers, chlorogenic acids from coffee increased fat burning during sleep [42, 43]. In mice infected with an antibiotic-resistant “superbug” (Staphylococcus aureus), chlorogenic acid prevented the harmful effects of the bacteria and reduced bacterial number. Chlorogenic acid (CGA) is the ester of caffeic acid and (−)-quinic acid, functioning as an intermediate in lignin biosynthesis. It also improved the function of their blood vessels [29]. Users wishing to obtain the effects of chlorogenic acid didn’t usually supplement with the purified substance, but with green coffee bean extract. Carlos spent 9 years in the laboratory investigating mineral transport in plants. It is also found in food sources such as apples, pears, eggplant, blueberries, tomatoes, strawberries, and potatoes [1, 2, 3, 4, 5]. It’s still in the animal and cell stage and further clinical studies have yet to determine if its extract may be useful in cancer therapies. In another trial on 16 obese individuals, green coffee bean extract taken for 22 weeks reduced weight, BMI, and body fat percentage [7]. Fourteen hybrids from a controlled cross between the seven F1 hybrids and, Seven hybrids from a controlled cross between, Potential Effects of Chlorogenic Acids on Platelet Activation, Animal studies suggest that CHAs are metabolized heavily by gut microbes, and their metabolites are detected mainly in plasma. Our website services, content, and products are for informational purposes only. [15], Chlorogenic is an important and biologically active dietary polyphenol, playing several important and therapeutic roles such as antioxidant activity, antibacterial, hepatoprotective, cardioprotective, anti-inflammatory, antipyretic, neuroprotective, anti-obesity, antiviral, anti-microbial, anti-hypertension, free radicals scavenger and a central nervous system stimulator. Journal of Agricultural and Food Chemistry, Journal of the Science of Food and Agriculture, 10.1002/(SICI)1097-0010(19990301)79:3<362::AID-JSFA256>3.0.CO;2-D, "Browning Potential, Phenolic Composition, and Polyphenoloxidase Activity of Buffer Extracts of Peach and Nectarine Skin Tissue", Critical Reviews in Food Science and Nutrition, "Chlorogenic acid (CGA): A pharmacological review and call for further research", The Journal of Allergy and Clinical Immunology, "Antihypertensive effects and mechanisms of chlorogenic acids", "Unremitting problems with chlorogenic acid nomenclature: a review", https://en.wikipedia.org/w/index.php?title=Chlorogenic_acid&oldid=980826222, Chemical articles with multiple compound IDs, Multiple chemicals in an infobox that need indexing, Chemical articles with multiple CAS registry numbers, Pages using collapsible list with both background and text-align in titlestyle, Articles containing unverified chemical infoboxes, Articles lacking reliable references from January 2017, Creative Commons Attribution-ShareAlike License, 207 to 209 °C (405 to 408 °F; 480 to 482 K), This page was last edited on 28 September 2020, at 18:01.

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